
Santa Cruz Island Vacations from $346
Book a Hotel + Flight or Car together to unlock savings
Photo by Sig
- Plan, book, travel with confidence
Better together
Save up to $1,045 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
The Latest Santa Cruz Island vacation packages
Price found within the past 48 hours. Click for updated prices.

Gran Hostal Tintorera
per person
Sep 8 - Sep 11
found 16 hours ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9/10 Wonderful! (100 reviews)
The owners were very friendly and welcoming. It appeared to be a family run establishment and they made sure we felt at home. Rooms are simple, clean and safe. A few blocks from the beach and close to all amenities.
Reviewed on Jul 17, 2025

La Casa de Marita
per person
Oct 10 - Oct 13
found 12 hours ago
Roundtrip flight included
Quito (UIO) to Isla Baltra (GPS)
9/10 Wonderful! (97 reviews)
We had a lovely night stay here. You’re on an island so some ants and bugs can be expected. This isn’t The Four Seasons so if you were looking for that you would be disappointed. What you will find staff willing to go above and beyond like Jonathan, who made our stay lovely. Love that you could just walk to the beach right behind the property. The peace and tranquillity you will find here is unmatched. I think this is the best place to stay on the island. We will definitely be returning.
Reviewed on May 14, 2025


Hotel Palace Galapagos
per person
Oct 17 - Oct 22
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9.8/10 Exceptional! (92 reviews)
The best place to stay! The staff were always helpful and they helped me keep my reservation when flight was not able to happen at last minute. They kept rooms cleaned phenomenally everyday. I did not want to leave. The location to downtown and harbor was excellent yet far enough from the noise! Never miss a chance to stay there!
Reviewed on Apr 1, 2025

Mi Playa Galapagos Beachfront
per person
Oct 15 - Oct 20
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Isla Baltra (GPS)
8.8/10 Excellent! (5 reviews)
Beautiful view, close to restaurants bars and restaurants.
The owner was very nice, breakfast was wonderful.
Really luxury place. We miss that place..
Reviewed on May 11, 2023
Don't see what you're looking for?
See all available trips from Columbus to Santa Cruz Island
View all tripsDiscover the most popular places to visit in Santa Cruz Island

Tortuga Bay Beach
5/5(89 reviews)
If a restful vacation is part of your travel plans, Tortuga Bay Beach might be the perfect place to seek out during your trip to Bella Vista. While you're in the area, wander around the parks.

Charles Darwin Research Station
4.5/5(131 reviews)
You can spend time exploring the galleries in Charles Darwin Research Station in Puerto Ayora. Wander the waterfront and beaches in the area.

El Garrapatero Beach
4.5/5(28 reviews)
Why not spend a carefree afternoon at El Garrapatero Beach during your travels in El Cascajo? While you're in the area, wander around the parks.
What to do in Santa Cruz Island

Full Day Tour Pinzon Island + La Fe/Las Palmas - Snorkeling & Fishing
$169
per adult

Tour of the city to Isabela + Tintoreras from Santa Cruz
$256
per adult

Transfer Baltra Airport - Hotel in Santa Cruz including a Highlands Tour
$289
per adult
100% of travellers recommend
Santa Cruz Island Hotel Deals

Hotel Fiesta
Calle Moises Brito y Juan Montalvo, Puerto Ayora, Galapagos
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $155 total per night from Aug 3 to Aug 4
$155 total
Aug 3 - Aug 4
9/10 Wonderful! (351 reviews)
Helpful Staff and Great Location
"The staff was very helpful and the hotel was in a safe and quiet location. The pool was cold but nice and the pillows were some of the most comfortable I’ve ever slept on."
Reviewed on Jul 25, 2025

Ikala Galapagos Hotel
Tomas de Berlanga 110 y Moises Brito, Puerto Ayora, Ecuador
$240 nightly
The price is $264 total per night from Aug 3 to Aug 4
$264 total
Aug 3 - Aug 4
9.6/10 Exceptional! (114 reviews)
"Beds too hard"
Reviewed on May 28, 2025

El Barranco Galapagos
Los colonos, Puerto Ayora, Galapagos
$183 nightly
The price is $183 total per night from Sep 2 to Sep 3
$183 total
Sep 2 - Sep 3
9.2/10 Wonderful! (11 reviews)
"amazing hotel and the best service the pool is the perfect spot to see seals, sea turtles, sting rays, sharks and pelicans , at night it’s quiet and the room was perfect. loved especially my balcony overlooking the docks."
Reviewed on Jul 6, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
More vacations you might like
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- Bellavista Hotels
- B&B in Bellavista
- Galápagos Hotels
- Resorts & Hotels with Spas in Galápagos
- Honeymoon Resorts & in Galápagos
- Family Hotels in Galápagos
- Hotel Wedding Venues Hotels in Galápagos
- Luxury Hotels in Galápagos
- Hostels in Galápagos
- Hotels with Tennis Courts in Galápagos
- Villas in Galápagos
- Beach Hotels in Galápagos
- Apartments in Galápagos
- Green Hotels in Galápagos
- Vacation Homes in Galápagos
- Historic Hotels in Galápagos
- Cheap Hotels in Galápagos
- Hotels with Suites in Galápagos
- Romantic Hotels in Galápagos
- Oceanfront Hotels in Galápagos
- Pet-friendly Hotels in Galápagos
- Guest Houses in Galápagos
- Hotels with a View in Galápagos
- Hotels with Free Breakfast in Galápagos
- Hotels with a Gym in Galápagos
- B&B in Galápagos
- Lodges in Galápagos
- Hotels with Air Conditioning in Galápagos
- Cabin Rentals in Galápagos
- Boutique Hotels in Galápagos
- Hotels with an Outdoor Pool in Galápagos
- Santa Rosa Hotels
- 4 Star Hotels in Santa Rosa
- Puerto Ayora Hotels
- Hotels with Tennis Courts in Puerto Ayora
- Hotels with Free Airport Shuttle in Puerto Ayora
- Hotels with Laundry Facilities in Puerto Ayora
- Hotels with Restaurants in Puerto Ayora
- Apartments in Puerto Ayora
- B&B in Puerto Ayora
- Cheap Hotels in Puerto Ayora
- Luxury Hotels in Puerto Ayora
- Beach Hotels in Puerto Ayora
- Hostels in Puerto Ayora
- Oceanfront Hotels in Puerto Ayora
- Hotels with a Gym in Puerto Ayora
- Honeymoon Resorts & in Puerto Ayora
- Gay friendly Hotels in Puerto Ayora
- Lodges in Puerto Ayora
- Hotels with a Pool in Puerto Ayora
- Hotel with a Concierge Hotels in Puerto Ayora
- Romantic Hotels in Puerto Ayora
- Hotels with Childcare in Puerto Ayora
- Hotels near Charles Darwin Research Station
- Hotels near Malecon
- Hotels near Academy Bay
- Hotels near Playa de los Alemanes
- Hotels near Las Grietas
- El Cascajo Hotels
- Hotels near El Garrapatero Beach
- Hotels near South Plaza Island
- Bellavista Vacations
- Galápagos Vacations
- Visit Bellavista
- All inclusive Vacation Packages Galápagos
- Santa Rosa Vacations
- Visit Galápagos
- Luxury Vacation Packages Galápagos
- Visit Santa Rosa
- Rancho Primicias
- Puerto Ayora Vacations
- Visit Puerto Ayora
- Charles Darwin Research Station
- Malecon
- Academy Bay
- Playa de los Alemanes
- Las Grietas
- Tortuga Bay Beach
- El Cascajo Vacations
- El Garrapatero Beach
- Visit El Cascajo
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.